Samantha Solon-Biet MD PhD

Nutrition,
metabolism
& healthy ageing

Investigating how what we eat shapes how we age. My research explores the role of macronutrients and dietary balance in metabolism, reproduction, behaviour, and age-related disease. I am currently working as a medical doctor at Concord Hospital, where I am developing my clinical skills with the goal of integrating research and practice — using the questions that emerge at the bedside to find novel solutions and drive meaningful improvements in patient outcomes.

Dietary protein Macronutrient balance FGF21 Longevity Branched-chain amino acids

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Positions

Medical Doctor, Concord Hospital Affiliate Senior Research Fellow, Charles Perkins Centre, University of Sydney

Focus areas

Current research projects

Low protein, high carbohydrate diets & healthy ageing

Exploring how dietary macronutrient ratios — particularly reduced protein and elevated carbohydrate — influence longevity and healthspan, and how these compare to calorie restriction.

Branched-chain amino acids in long-term health

Investigating how specific amino acids regulate metabolic signalling pathways and contribute to age-related disease risk, with implications for dietary guidelines.

FGF21 as master regulator of protein intake

Testing whether the hormone FGF21 acts as a central signal mediating appetite for protein and driving metabolic adaptation to dietary protein restriction.

Optimising diet for reproduction & lifespan

Examining the nutritional trade-offs between reproductive success and longevity, seeking dietary strategies that support both — with implications for preconception health.

Public engagement